Viral genomes {can be|may be|could be|might be|is often|is usually} compressed into a {near|close to} spherical nanochamber to {form|type|kind} infected particles. {In order to|To be able to|As a way to|In an effort to|So as to|So that you can} mimic the virus morphology and packaging behavior, we invented a programmable icosahedral DNA nanoframe with enhanced rigidity and encapsulated the phiX174 bacteriophage genome. The packaging efficiency {could be|might be|could possibly be|may be|may very well be} modulated {through|via|by means of|by way of} {specific|particular|certain|distinct|precise} anchoring strands adjustment, {and the|and also the|as well as the|along with the|plus the} enveloped phage genome remained accessible for enzymatic operations. {Moreover|Furthermore|In addition|Additionally}, the packed {complex|complicated} could infect E. coli cells {through|via|by means of|by way of} bacterial uptake then {produce|create|generate|make} plaques. This rigid icosahedral DNA architecture established a versatile platform to {develop|create} virus mimetic particles for {convenient|handy|hassle-free|practical|easy} nucleic acid entrapment, manipulation and delivery. 936637-97-7 custom synthesis 5458-56-0 site PMID:24834360
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