Dearomatized indole derivatives bearing a C3- or C2-stereocenter exist ubiquitously in {natural|all-natural|organic} {products|goods|items|merchandise|solutions} and biologically active molecules. {Despite|Regardless of|In spite of} {remarkable|outstanding|exceptional} advances in their chemical synthesis, stereoselective and regio-divergent {methods|techniques|strategies|approaches|procedures|solutions} are {still|nonetheless|nevertheless} {in a|inside a|within a} {high|higher} demand. Herein, a Pd-catalyzed intermolecular asymmetric spiroannulation of {2|two},3-disubstituted indoles with internal alkynes has been {developed|created} for the {efficient|effective} {construction|building} of indoline structures {with a|having a|using a} C2-quaternary stereocenter. Stereospecific aza-semipinacol rearrangement {of these|of those} indoline derivatives {under|below|beneath} acidic {conditions|circumstances|situations} afforded indolenine {products|goods|items|merchandise|solutions} bearing a C3-quaternary stereocenter, {where|exactly where} the selectivity for the rearranging group {could be|might be|could possibly be|may be|may very well be} controlled by the reaction sequence. The asymmetric spiroannulation {together|with each other|collectively} {with the|using the|with all the|together with the} subsequent aza-semipinacol rearrangement enabled a divergent access to dearomatized indole derivatives with either a C3- {or a|or perhaps a|or even a|or possibly a|or maybe a} C2-quaternary stereocenter. 3-Phenoxyaniline manufacturer Buy2-Azidoethyl 4-methylbenzenesulfonate PMID:24118276
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