Herein, we describe a chemoenzymatic synthesis {of the|from the|in the|on the|with the|of your} bicyclic fragment of Darunavir. A ketoreductase was identified {using|utilizing|making use of|employing|working with|applying} metagenomic mining to catalyze a {highly|extremely|very|hugely} enantio- and diastereoselective dynamic kinetic resolution of a 𝛽-ketolactone. Subsequent lactone reduction with diisobutylaluminium hydride and phase transfer cyclization affords the bicyclic acetal fragment in 39% yield {over|more than} {four|4} {steps|actions|measures|methods}. 4-Ethynylpiperidine hydrochloride Chemical name 1951466-68-4 uses PMID:23927631
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