Hydroxylative dearomatization reactions of phenols (HPD) {offer|provide|supply|offer you|present|give} an {efficient|effective} {way to|method to|approach to|strategy to|technique to|solution to} assemble {complex|complicated}, biologically relevant scaffolds. {Despite|Regardless of|In spite of} this, enantioselective hydroxylative phenol dearomatizations for the {construction|building} of bicy-clo[2.{2|two}.2]octenones are classically {limited|restricted} to stoichiometric chiral reagents, {and a|along with a|as well as a|plus a|and also a|in addition to a} {practical|sensible}, enantioselective catalytic {method|technique|approach|strategy|system|process} has remained elusive. Herein, we describe a {highly|extremely|very|hugely} enantioselective, organocatalytic tandem o-HPD-[4+2] reaction. Our methodology utilizes a chiral oxaziridinium organocatalyst that affords {high|higher} enantioselectivity {for a|to get a|for any} wide {range of|selection of|array of} phenol substitution patterns, and was applied {in the|within the|inside the} synthesis of (+)-biscarvacrol and bis({2|two},6-xylenol). The practicality of our {conditions|circumstances|situations} {were|had been|have been} demonstrated at gram-scale, {using|utilizing|making use of|employing|working with|applying} an amine precatalyst {that can|that may|that will|that could|which will|which can} be accessed {in a|inside a|within a} single synthetic step. 5-Bromo-1H-1,2,4-triazol-3-amine Price 3-(Dibenzylamino)propan-1-ol Data Sheet PMID:35345980
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