Amidines are a ubiquitous class of bioactive compounds {found|discovered|identified|located} {in a|inside a|within a} wide {variety|selection|assortment|range|wide variety} of {natural|all-natural|organic} {products|goods|items|merchandise|solutions}; {thus|therefore|hence|as a result}, {efficient|effective} strate-gies for their preparation are in {great|fantastic|excellent|wonderful|good|terrific} demand. {Specifically|Particularly|Especially}, their {common|typical|frequent|widespread|prevalent|popular} structural core decorated with {three|3} substitu-ents, set amidines as {perfect|ideal|excellent|best|great|fantastic} candidates for multicomponent synthesis. Herein, we present a {highly|extremely|very|hugely} modular metal-free multicomponent {strategy|technique|method|approach|tactic} for the synthesis of sulfonyl amidines. This {work|function|perform|operate} was focused on {selecting|choosing|picking|deciding on} readily accessible reagents to facilitate the in situ formation of enamines by the addition of amines to ketones. These {components|elements} {were|had been|have been} coupled with azides {to provide|to supply} a broad reaction scope with respect to all {three|3} coupling partners. Aromatic and aliphatic amines and ketones {were|had been|have been} tolerated {under|below|beneath} our reaction {conditions|circumstances|situations}. Likewise, the presence of a methyl group {on the|around the} ke-tone was {critical|crucial|vital|essential|important} to reactivity, which was leveraged for the {design|style|design and style} of a {highly|extremely|very|hugely} regioselective reaction with aliphatic ke-tones. A biologically active compound was {successfully|effectively} synthesized in {one|1|a single|one particular} step, demonstrating the {practical|sensible} utility of our methodology. {Finally|Lastly|Ultimately}, the postulated mechanism was investigated and supported {both|each} experimentally and by {means|indicates|implies|signifies|suggests} of a multivariate statistical model. Price of G0-C14 58349-17-0 Order PMID:24140575
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