{Various|Numerous|Different|A variety of|Several|Many} post translational modifications like hyper phosphorylation, O-GlycNAcylation, and acetylation {have been|happen to be|have already been} attributed to induce the abnormal folding in tau protein. {Recent|Current} in vitro {studies|research} revealed the {possible|feasible|achievable|attainable|doable|probable} involvement of N–glycosylation of tau protein {in the|within the|inside the} abnormal folding and tau aggregation. {Hence|Therefore} {in this|within this} study, we performed microsecond {long|lengthy|extended} all atom molecular dynamics simulation to {gain|acquire|obtain|achieve|get} insights {into the|in to the} effects of N-glycosylation on Asn-359residue which {forms|types} {part of|a part of} the microtubule binding {region|area}. Trajectory {analysis|evaluation} {of the|from the|in the|on the|with the|of your} stimulations coupled with {essential|important|crucial|vital|necessary|critical} dynamics and {free|totally free|free of charge|cost-free|absolutely free|no cost} {energy|power} landscape {analysis|evaluation} {suggested|recommended} that tau, in its N-glycosylated {form|type|kind} {tend to|have a tendency to|often|are inclined to|are likely to|usually} exist {in a|inside a|within a} largely folded conformation {having|getting|possessing|obtaining} {high|higher} beta sheet propensity as {compared to|in comparison to|in comparison with|when compared with} unmodified tau which exists {in a|inside a|within a} {large|big|huge|massive|substantial|significant} extended {form|type|kind} with {very|extremely|really|quite|incredibly|pretty} {less|much less|significantly less} beta sheet propensity. Residue interaction network {analysis|evaluation} {of the|from the|in the|on the|with the|of your} lowest {energy|power} conformations {further|additional} revealed that Phe378 and Lys353 {are the|would be the|will be the} functionally {important|essential|crucial|critical|significant|vital} residues {in the|within the|inside the} peptide which helped in initiating the folding {process|procedure|method|approach|course of action} and Phe378, Lys347&Lys370 helped maintaining the stability {of the|from the|in the|on the|with the|of your} protein {in the|within the|inside the} folded state. tert-Butyl 2-diazoacetate uses Price of 942920-50-5 PMID:23664186
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