New neutralizing {strategies|methods|techniques|approaches|tactics} against SARS-CoV-2 and {associated|related|connected|linked} variants are urgently {needed|required|necessary} for the {treatment|therapy|remedy} of COVID-19. Targeting the SARS-CoV-2 multi-spike trimers, an icosahedral DNA framework was assembled to spatially arrange {up to|as much as} thirty neutralizing aptamers (IDNA-30) with nanometer precision to inhibit viral infection. {Each|Every|Each and every|Every single} triangular plane of IDNA-30 is composed of {three|3} precisely positioned aptamers topologically matching SARS-CoV-2 spike trimer, {thus|therefore|hence|as a result} forming a multivalent spatially patterned binding. {Additionally|In addition|Furthermore|Moreover|Also|On top of that}, {due to|because of|as a result of|on account of|resulting from|as a consequence of} its {multiple|numerous|several|a number of|many|various} binding {sites|websites|web sites|internet sites|web-sites|web pages} and moderate size, multifaced IDNA induces aggregation of viruses. {Moreover|Furthermore|In addition|Additionally}, the rigid icosahedron framework afforded by four-helixes {not only|not just|not merely|not simply} {forms|types} a steric barrier {to prevent|to stop} the virus from binding to host, {but also|but additionally|but in addition} limits the conformational transformation of SARS-CoV-2 spike trimer. Combining multivalent topologically patterned aptamers with structurally well-defined nano-formulations, IDNA-30 exhibits {excellent|superb|outstanding|exceptional|great|fantastic} neutralization against SARS-CoV-2 {and a|along with a|as well as a|plus a|and also a|in addition to a} broad neutralizing activity against {several|a number of|numerous|many|various|quite a few} mutant strains. {Overall|General|All round}, this spatially matched neutralizing {strategy|technique|method|approach|tactic} {provides|offers|gives|supplies|delivers} {a new|a brand new} {direction|path} for the assembly of neutralizing reagents to {enhance|improve|boost} the inhibitory {effect|impact} of SARS-CoV-2 infection and combat other disease-causing viruses. 1256825-86-1 Chemscene 4-Methylbenzene-1,3-diol Chemscene PMID:24982871
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