Mutually orthogonal bioorthogonal reactions are a thriving {area|region|location} of {research|study|analysis|investigation} in chemical biology. {Here|Right here} we present a predictive-driven {approach|method|strategy} to {identify|determine|recognize} mutually orthogonal pairs {among|amongst} two bioorthogonal reactions: the metal-free 1,3-dipolar cycloaddition (1,3-DC) reaction {and the|and also the|as well as the|along with the|plus the} inverse electron-demand Diels–Alder (IEDDA) reaction. Parametrization of {both|each} 1,3-dipoles and dipolarophiles structures {allowed|permitted} the {development|improvement} of statistically robust models for predicting the second order {rate|price} constants of 1,3-DC reactions. {Combination|Mixture} of predictive models {were|had been|have been} {used|utilized|employed|utilised|applied|made use of} to {identify|determine|recognize} {potential|possible|prospective} mutually orthogonal reactions {among|amongst} sets of structurally {different|various|distinct|diverse|unique|distinctive} pairs. 3-(Trifluoromethyl)-1H-indazole Chemical name 2-Amino-4-bromo-3-fluorobenzoic acid manufacturer PMID:36014399
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