The direct α-arylation of unactivated carbonyl compounds {using|utilizing|making use of|employing|working with|applying} aryl halides represents a {powerful|potent|effective|strong|highly effective} {method|technique|approach|strategy|system|process} to synthesize criti-cal {building|developing|creating|constructing} blocks for diverse {useful|helpful|beneficial|valuable} compounds. {Numerous|Many|Several|Quite a few|A lot of|Various} synthetic {methods|techniques|strategies|approaches|procedures|solutions} exist to forge C(sp2)-C(sp3) bonds, albeit metal {free|totally free|free of charge|cost-free|absolutely free|no cost} direct α-arylation of unactivated cyclic ketones has {long|lengthy|extended} been an elusive transformation. Herein, we report a green-light-mediated α-arylation of unactivated ketones from readily {available|accessible|obtainable|offered|readily available|out there} aryl halides {via|by way of|through|by means of} activation of a C(sp2)-X bond (X=I, Br, Cl) and an α-carbonyl C(sp3)-H bond {in a|inside a|within a} single photocatalytic cycle. This {approach|method|strategy} is characterized by its mild reaction {conditions|circumstances|situations}, operational simplicity, and wide functional group tolerance. Importantly, the impressive outcome from multi-gram photocatalytic reaction underpins the strength of this {method|technique|approach|strategy|system|process} as a potentially {practical|sensible} and {attractive|appealing|desirable|eye-catching} {approach|method|strategy} for scale-up industrial purposes. The utility and scope of this reaction {were|had been|have been} {further|additional} demonstrated by new syntheses of {several|a number of|numerous|many|various|quite a few} feedstock {chemicals|chemical substances|chemical compounds} {that are|which are|which can be|which might be|that happen to be} commercially {expensive|costly|pricey|high-priced|high priced|highly-priced} but {critical|crucial|vital|essential|important} for synthesizing {numerous|many|several|quite a few|a lot of|various} pharmaceutical agents. 2-Amino-2-methyl-1-propanol web Price of 1,3-Diiodo-5,5-dimethylhydantoin PMID:27017949
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