Alkane functionalization with carbon-electrophiles remains {virtually|practically} unexplored {under|below|beneath} thermo-driven hydrogen atom transfer (HAT) {conditions|circumstances|situations} {due to|because of|as a result of|on account of|resulting from|as a consequence of} a challenge of integrating oxidation and reduction {in a|inside a|within a} single operation. We report {here|right here} a Ni-catalyzed arylation and alkylation of alkane C‒H bonds with organohalides to forge C(sp3)‒C bonds by merging {easily|effortlessly|very easily|simply|quickly|conveniently} accessible Zn and tBuOOtBu (DTBP) {as the|because the} external reductant and oxidant. The mild and easy-to-operate protocol enables facile carbofunctionalization of N-/O-α- and cyclohexane CH bonds, and preparation of {a number of|numerous|several|quite a few|a variety of|many} bioactive compounds and drug derivatives. Preliminary mechanistic {studies|research} implied a Ni(I)-mediated DTBP reduction followed by alkane HAT to tBuO radical. The marked compatibility of Zn and DTBP with nickel-catalysis {may|might|could|may possibly|may well|may perhaps} invoke the {development|improvement} of external oxidant and reductant co-trigged thermoredox bond forming approaches {based|primarily based} upon {challenging|difficult} substrates. 1450754-38-7 In stock DOTA-tris(tBu)ester NHS ester web PMID:32926338
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