Photolabile {Protecting|Guarding|Defending|Safeguarding} Groups (PPGs) are chemical tools {used|utilized|employed|utilised|applied|made use of} in photopharmacology for the oxygen-independent release of bioactive payloads, enabling spatiotemporal activation of their bioactivity. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, red-shifting of PPG activation wavelengths {into the|in to the} NIR {range|variety}, light which penetrates the deepest in tissue, has been laborious, and {often|frequently|usually|typically|generally|normally} {results|outcomes|final results|benefits} in inefficient or insoluble PPGs. This challenge prohibits {the use of|the usage of} {current|present|existing} photocages in {complex|complicated} biological targets, hindering the progression of photopharmacology {into the|in to the} clinic. To {directly|straight} address this {problem|issue|difficulty|dilemma|challenge|trouble}, we report herein a novel {concept|idea|notion} in PPG {design|style|design and style}, by transforming clinically-applied NIR-dyes with {suitable|appropriate} molecular orbital configurations into new NIR-PPGs {using|utilizing|making use of|employing|working with|applying} computational approaches. {Using|Utilizing|Making use of|Employing|Working with|Applying} this {method|technique|approach|strategy|system|process}, we demonstrate how Cy7, a class of clinically-employed NIR dyes possessing {ideal|perfect|best|excellent} properties, {such as|like|including|for example|for instance|which include} NIR-absorption, {very|extremely|really|quite|incredibly|pretty} {high|higher} molecular absorptivity, and {excellent|superb|outstanding|exceptional|great|fantastic} solubility in aqueous media, {can be|may be|could be|might be|is often|is usually} {successfully|effectively} converted into Cy7-PPG. We report a facile organic synthesis towards Cy7-PPG from {easily|effortlessly|very easily|simply|quickly|conveniently} accessible precursors and confirm its function as an oxygen-independent NIR-PPG. Cy7-PPG {is the|will be the|may be the|would be the|could be the|is definitely the} most redshifted PPG to date (max wavelength = 746 nm), with unmatched molecular absorptivity and solubility, and {excellent|superb|outstanding|exceptional|great|fantastic} uncaging efficiency, paving the way for {the use of|the usage of} PPGs {in the|within the|inside the} clinic. 1638760-65-2 Chemical name 22112-84-1 Price PMID:24360118
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