Photoswitchable reagents to modulate protein activity are {powerful|potent|effective|strong|highly effective} tools for high-spatiotemporal-precision {control|manage|handle} {over|more than} endogenous biological functions. TRPC5 {is a|is really a|is actually a|can be a|is often a|is usually a} Ca2+-permeable cation channel with distinct tissue-specific roles, ranging from synaptic function to hormone regulation. {Achieving|Reaching|Attaining} spatially-resolved {control|manage|handle} {over|more than} TRPC5 activity in {particular|specific|certain|distinct|unique} cells or tissues, and temporal regulation in targeted cells, are {therefore|consequently|as a result|for that reason|thus|hence} {crucial|essential|vital|critical|important} milestones towards understanding and harnessing the biology of TRPC5. {Here|Right here} we {develop|create} {the first|the very first|the initial} photoswitchable TRPC5-modulating reagent, BTDAzo, towards reaching this {goal|objective|aim|purpose|target}. BTDAzo can photocontrol TRPC5 currents in cell culture, {as well as|in addition to|along with|and also|together with|and} controlling endogenous TRPC5-based neuronal Ca2+ responses in mouse brain slices. BTDAzos are also {the first|the very first|the initial} reported azo-benzothiadiazines, an accessible and conveniently derivatised azoheteroarene that {features|attributes|functions|characteristics|capabilities|options} {excellent|superb|outstanding|exceptional|great|fantastic} two-colour photoswitching. BTDAzo’s TRPC5 {control|manage|handle} across relevant channel biology settings {makes|tends to make} it {appropriate|suitable|proper|acceptable} {for a|to get a|for any} {range|variety} of dynamically reversible photoswitching {studies|research} in TRP channel biology, aiming to decipher the {various|numerous|different|a variety of|several|many} biological roles of this centrally {important|essential|crucial|critical|significant|vital} ion channel. 1-Bromobutan-2-one Chemical name Fmoc-L-Lys(ivDde)-OH site PMID:24360118
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