Protein-protein interactions play a {key|important|crucial|essential} {role|function|part} in cell homeostasis and physiological functions {of the|from the|in the|on the|with the|of your} organisms. Consequently, their malfunction {leads to|results in} {diseases|illnesses|ailments} {such as|like|including|for example|for instance|which include} cancer, metastasis and neurodegeneration. The Hub1/Snu66 interaction is {responsible|accountable} for controlling {alternative|option} splicing {through|via|by means of|by way of} non-covalent binding {to the|towards the|for the} HIND (Hub1-Interacting Domain) domain {of the|from the|in the|on the|with the|of your} Snu66 spliceosomal protein. To {better|much better|far better|greater|superior|improved} {understand|comprehend|realize|recognize|fully grasp|have an understanding of} how Hub1 {works|functions|operates|performs} in living organisms, we {conducted|performed|carried out} a study {to find|to locate|to discover|to seek out} {small|little|tiny|modest|smaller|compact} molecules {that have|which have} an affinity for the Snu66 binding {site|website|web site|internet site|web-site|web page} of Hub1. The in silico investigation was {based|primarily based} on {global|international|worldwide} peptide modeling followed by high-resolution protein-peptide refinement. Docking {analysis|evaluation} of {nearly|almost|practically} 200 molecules {in the|within the|inside the} binding pocket of Hub1 {is also|can also be} described. {Finally|Lastly|Ultimately}, Nuclear Magnetic Resonance fragment-based screening was {used|utilized|employed|utilised|applied|made use of} to confirm our findings. 1300746-79-5 site Buy2-Chloro-4,6-dimethoxyaniline PMID:23937941
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