The biological and therapeutic significance of polyketides {is a|is really a|is actually a|can be a|is often a|is usually a} {powerful|potent|effective|strong|highly effective} impetus for the {development|improvement} of {efficient|effective} {methods|techniques|strategies|approaches|procedures|solutions} to facilitate their {construction|building}. Emulating the efficiency of polyketide biosynthesis, a sophisticated arsenal of aldol-based {strategies|methods|techniques|approaches|tactics} has evolved {that is|that’s|which is|that is certainly|that is definitely|that may be} contingent {on the|around the} generation of single enolate isomers. {Since|Because|Given that|Considering that|Due to the fact|Considering the fact that} this has the {potential|possible|prospective} to compromise efficiency in reagent-based paradigms, direct catalysis-based {solutions|options} {would be|could be|will be} enabling. To complement the array of substrate-based {strategies|methods|techniques|approaches|tactics}, and regulate enolate geometry {at the|in the} catalyst level, a direct catalytic alkylation of esters with oxyallenes has been {developed|created}. Synergizing metal hydride reactivity with Lewis base catalysis has resulted {in a|inside a|within a} broad reaction scope with {useful|helpful|beneficial|valuable} levels of stereocontrol ({up to|as much as} >99% ee). Facile derivatization {of these|of those} ambiphilic linchpins is demonstrated, {providing|supplying|offering|delivering|giving} access to high-value vicinal stereocenter-containing motifs, {including|such as|which includes|like} 1,2-amino alcohols. (R)-(Tetrahydrofuran-2-yl)methanol web 1015610-39-5 Purity PMID:24360118
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