Ladderane phospholipids, with their {unusual|uncommon} ladder-like arrangement of fused cyclobutane rings, represent an architecturally {unique|distinctive|special|exclusive|exceptional|one of a kind} class of {natural|all-natural|organic} {products|goods|items|merchandise|solutions}. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, {despite|regardless of|in spite of} their fascinating structure {and other|as well as other|along with other|and also other} {necessary|essential|required|needed|important|vital} impetus, only {a few|a couple of|several|a number of|some|a handful of} synthetic {studies|research} {of these|of those} molecules {have been|happen to be|have already been} reported so far. {We have|We’ve|We’ve got} now devised a concise synthesis of [3]-ladderanol, a {component|element} of ladderane phospholipids, {using|utilizing|making use of|employing|working with|applying} an organocatalytic enantioselective desymmetrizing formal C(sp2)‒H alkylation. Our synthetic {strategy|technique|method|approach|tactic} rests on a late-stage introduction of chirality, {thus|therefore|hence|as a result} {allowing|permitting|enabling} facile access to {both|each} the enantiomers of [3] ladderanol {as well as|in addition to|along with|and also|together with|and} its analog. {This is|This really is|This can be|That is} {the first|the very first|the initial} time a desymmetrization {strategy|technique|method|approach|tactic} is applied {to the|towards the|for the} synthesis of [3]-ladderanol. The scope of this desymmetrizing C(sp2)‒H alkylation of meso cyclobutane fused cyclohexenediones {is also|can also be} presented. 1243313-06-5 Data Sheet 87727-28-4 Chemscene PMID:23892746
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