{Despite|Regardless of|In spite of} expanding therapeutic application of sunitinib and advances in its formulation, pharmacochemical and spectroscopical study on its aqueous {solution|answer|remedy|resolution|option} is rather insufficient {due to|because of|as a result of|on account of|resulting from|as a consequence of} poor solubility of its base or salt {form|type|kind}. {In this|Within this} report, ¹H (900 MHz) and ¹³C (225 MHz) NMR spectra of sunitinib malate in H₂O/D₂O=9/1 {have been|happen to be|have already been} analyzed, whose spectral peaks {have been|happen to be|have already been} assigned to {each|every|each and every|every single} hydrogen and carbon atom, assisted by a {combination|mixture} of two-dimensional homo- and heteronuclear NMR: COSY, HSQC-DEPT, and HMBC. The assignment of labile H-N hydrogens in ¹H NMR spectrum is of {particular|specific|certain|distinct|unique} interest in aqueous media, {where|exactly where} such labile hydrogens {could be|might be|could possibly be|may be|may very well be} potentially {affected|impacted} by intermolecular interactions (e.g., hydrogen bonding) with co-solvated constituents. Peak splitting patterns and corresponding ⁿJ(H-H), ⁿJ(H-F), and ⁿJ(C-F) coupling constants observed in {each|every|each and every|every single} assigned spectrum {have been|happen to be|have already been} jointly discussed, and ⁿJ(C-F) coupling constants {were|had been|have been} {compared to|in comparison to|in comparison with|when compared with} {those|these} taken in DMSO-d6. Cubane-1-carboxylic acid In stock 1338377-73-3 site PMID:23453497
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