Synthetic peptide conjugates {that can|that may|that will|that could|which will|which can} molecularly target and activate blood platelets are {designed|developed|created|made} for hemostasis applications. An engineered thrombin receptor-activating peptide (TRAP-Cys, SFLLRNPNC) is covalently attached to cell-compatible 8-arm poly (ethylene glycol) maleimides {via|by way of|through|by means of} Michael addition. {It is|It’s|It really is|It truly is|It can be|It is actually} proved that the {ability|capability|capacity|potential} of TRAP to activate platelets is retained {in the|within the|inside the} conjugated {form|type|kind} by {means|indicates|implies|signifies|suggests} of thromboelastometry, platelet aggregation assay and flow cytometry. A 0.{5|five} % PEG-TRAP {solution|answer|remedy|resolution|option} can {efficiently|effectively} activate platelets and shorten the clotting {time to|time for you to} ~45 %. 3-Amino-5-(tert-butyl)phenol Formula 1190310-00-9 site PMID:25016614
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