In October 2021, {a number of|numerous|several|quite a few|a variety of|many} batches of irbesartan and irbesartan hydrochlorothiazide {finished|completed} {products|goods|items|merchandise|solutions} {were|had been|have been} recalled {from the|in the} US {market|marketplace|industry|market place}, {due to|because of|as a result of|on account of|resulting from|as a consequence of} the presence of unacceptable {level of|degree of|amount of} the {probably|most likely|almost certainly|possibly|in all probability|likely} carcinogenic nitrosamine N-nitrosoirbesartan. {Nevertheless|Nonetheless}, {there is no|there isn’t any|there’s no|there is absolutely no} revealing {of the|from the|in the|on the|with the|of your} {exact|precise} structure of this hypothetical N-nitrosoirbesartan. {In the|Within the|Inside the} {current|present|existing} study, we performed a set of {10|ten} reactions of irbesartan with nitrous acid {under|below|beneath} {various|numerous|different|a variety of|several|many} {conditions|circumstances|situations} and {found|discovered|identified|located} no trace of this hypothetical N-nitrosoirbesartan by a sensitive and {accurate|correct|precise} LC-MS {method|technique|approach|strategy|system|process} with limit of detection (LOD) of 30 ppb. {With the|Using the|With all the|Together with the} use of LC-PDA/UV-high resolution MSn {as well|also|too|at the same time} as 1D/2D NMR, the reaction {products|goods|items|merchandise|solutions} formed are {found|discovered|identified|located} {to be|to become} the two isomeric oxime derivatives of irbesartan, {with the|using the|with all the|together with the} Z-isomer {as the|because the} predominant {product|item|solution}. {Furthermore|Moreover|In addition|Additionally}, no trace of this hypothetical N-nitrosoirbesartan {can be|may be|could be|might be|is often|is usually} detected in representative {commercial|industrial} batches of irbesartan. {Despite|Regardless of|In spite of} {of the|from the|in the|on the|with the|of your} {fact|reality|truth} that in silico evaluation suggests that the two irbesartan oximes {may be|might be|could be|could possibly be|can be|may very well be} controlled as {regular|normal|typical|standard|common|frequent} impurities, {analysis|evaluation} of representative irbesartan {commercial|industrial} batches by the LC-MS {method|technique|approach|strategy|system|process} indicates that the oximes {are not|aren’t|usually are not|will not be|are certainly not|are usually not} detected (LOD: 30 ppb). Apixaban Chemscene 2-(2,2-Difluorocyclopropyl)acetic acid Price PMID:32926338
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