{There is|There’s|There is certainly} {evidence|proof} that {high|higher} levels of folic acid in human plasma {may|might|could|may possibly|may well|may perhaps} {prevent|stop|avoid|avert|protect against} SARS-CoV-2 infections or {reduce|decrease|minimize|lessen|lower|cut down} its symptoms. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the mechanisms that {enable|allow} this inhibition are {still|nonetheless|nevertheless} unknown. {This article|This short article} proves, {through|via|by means of|by way of} molecular dynamics simulation, that folic acid metabolite 7,8-dihydrofolate (DHF) has {high|higher} affinity to bind as ligands {to the|towards the|for the} angiotensin-converting enzyme {2|two} (ACE2), and when this {complex|complicated} has been formed, the Wild {type|kind|sort|variety|form} SARS-CoV-2 virus {cannot|can’t|can not} bind {to the|towards the|for the} ACE2 receptor, possibly inhibiting infection {to the|towards the|for the} host cell. In contrast, the Beta and Delta variants of this {same|exact same|identical|very same|similar} virus can join the ACE2 with {high|higher} affinity even {with the|using the|with all the|together with the} presence of DHF. This {results|outcomes|final results|benefits} {lead to|result in|bring about|cause} the conclusion that DHF {may|might|could|may possibly|may well|may perhaps} inhibit infection {from the|in the} Wild {type|kind|sort|variety|form} SARS-CoV-2 virus, but not its Beta and Delta variants.These {results|outcomes|final results|benefits} could {explain|clarify} the {almost|nearly|virtually|practically|just about|pretty much} double {increase|improve|boost|enhance|raise} in {severe|serious|extreme} {cases|instances|circumstances|situations} of COVID-19 {due to|because of|as a result of|on account of|resulting from|as a consequence of} the delta variant in pregnant {women|ladies|females|girls} {compared to|in comparison to|in comparison with|when compared with} the Wild {type|kind|sort|variety|form} SARS-CoV-2. tert-Butyl (2-iodoethyl)carbamate Price Price of 1196145-01-3 PMID:23983589
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