The moiety of 4-imidazolidinone {is an|is definitely an} {important|essential|crucial|critical|significant|vital} structural motif in organic synthesis and medicinal chemistry. We {achieved|accomplished} the {efficient|effective} synthesis of 4-imidazolidinones from {a variety of|a number of|many different|various|a range of|several different} diamides by double Michael addition, a novel reaction mode for hypervalent alkynyl iodine compounds, {and a|along with a|as well as a|plus a|and also a|in addition to a} formal reductive elimination sequence {using|utilizing|making use of|employing|working with|applying} in situ-generated EBX from TMS-EBX or EBX-MeCN. The {highly|extremely|very|hugely} reactive EBX enabled chemoselective intermolecular N- alkenylation {of the|from the|in the|on the|with the|of your} sulfonamide moiety and intramolecular cyclization {of the|from the|in the|on the|with the|of your} amide moiety {under|below|beneath} mild {basic|fundamental|simple|standard} {conditions|circumstances|situations}. The reaction diastereoselectively gave cis-2,5-disubstituted 4-imidazolidinones from amino acid-derived diamides. {Furthermore|Moreover|In addition|Additionally}, 2-[(2-iodobenzoyloxy)methyl]-4-imidazolidinone was derivatized by solvolysis and Sonogashira coupling. DFT calculations indicated that the double Michael addition mechanism is plausible. {Thus|Therefore|Hence|As a result}, the {potential|possible|prospective} of an unsubstituted EBX reagent for the synthesis of heterocycles from {complex|complicated} molecules and their functionalization with mild nucleophiles was demonstrated. 3-Methoxy-2,6-dimethyl-aniline Chemical name Buy5-Methoxyquinazolin-4(3H)-one PMID:34856019
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