Pd(II)-catalyzed site-selective β- and γ-C(sp3)−H arylation of {primary|main|major|principal|key} aldehydes is {developed|created} by rational {design|style|design and style} of L,X-type transient directing groups (TDG). External 2-pyridone ligands are identified {to be|to become} {crucial|essential|vital|critical|important} for the observed reactivity. By minimizing the loading of acid additives, the ligand {effect|impact} is enhanced {to achieve|to attain} {high|higher} reactivities {of the|from the|in the|on the|with the|of your} {challenging|difficult} {primary|main|major|principal|key} aldehyde substrates. Site-selectivity {can be|may be|could be|might be|is often|is usually} switched {from the|in the} proximate {to the|towards the|for the} {relatively|fairly|comparatively|reasonably|somewhat} remote position by {changing|altering} the bite angle of TDG to match the {desired|preferred} palladacycle size. Experimental and computational investigations {support|assistance|help} this rationale for designing TDG to potentially {achieve|attain|accomplish|obtain|realize|reach} remote site-selective C(sp3)−H functionalizations. 1500974-00-4 Data Sheet BuyMethyl 2-(4-hydroxyphenyl)-2-oxoacetate PMID:23892407
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