We report the {development|improvement} of HaloTag fluorogens {based on|according to|depending on|determined by} dipolar {flexible|versatile} molecular rotor structures. By modulating the electron donating and withdrawing groups, {we have|we’ve|we’ve got} tuned the absorption and emission wavelengths to {design|style|design and style} a palette of fluorogens with emissions spanning the green to red {range|variety}. The probes {were|had been|have been} studied in glycerol and in presence of HaloTag and exhibited {good|great|excellent|very good|fantastic|superior} fluorogenic properties {thanks to|due to|because of} a viscosity-sensitive emission. In live-cell confocal imaging, the fluorogens yielded only {a very|a really|an extremely|an incredibly} low non-specific signal that enabled wash-free targeted imaging of intracellular organelles and proteins with {good|great|excellent|very good|fantastic|superior} contrast. 4-Bromo-6-chloropyridin-2(1H)-one Purity 1,2-Benzisoxazol-6-amine Order PMID:24220671
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