{In this|Within this} paper, we present an unprecedented and {general|common|basic} umpolung protocol that {allows|enables|permits|makes it possible for} the functionalization of silyl enol ethers and of 1,3-dicarbonyl compounds {with a|having a|using a} {large|big|huge|massive|substantial|significant} {range of|selection of|array of} heteroatomic nucleophiles, {including|such as|which includes|like} carboxylic acids, alcohols, {primary|main|major|principal|key} and secondary amines, azide, thiols, {and also|as well as} anionic carbamates derived from CO2. The scope {of the|from the|in the|on the|with the|of your} reaction also extends to carbon-based nucleophiles. The reaction relies {on the|around the} use of 1-bromo-3,3-dimethyl-1,3-dihydro-1delta3[d][1,2]iodaoxole, which {provides|offers|gives|supplies|delivers} a {key|important|crucial|essential} alpha-brominated carbonyl intermediate. The reaction mechanism has been studied experimentaly and by DFT, and we propose formation of an {unusual|uncommon} enolonium intermediate {with a|having a|using a} halogen-bonded bromide. Buy6-Methoxy-5-nitropicolinic acid (S)-3-Phenylmorpholine custom synthesis PMID:23291014
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