We demonstrate {here|right here} {using|utilizing|making use of|employing|working with|applying} a disulfide {system|method|program|technique} {the first|the very first|the initial} {example|instance} of reversible, selective and quantitative transformation {between|in between|among|amongst|involving} {three|3} crystalline polymorphs by ball mill grinding. This {includes|consists of|contains|involves|incorporates} the discovery of a previously unknown polymorph. {Each|Every|Each and every|Every single} polymorph is reproducibly obtained {under|below|beneath} well-defined neat or liquid-assisted grinding {conditions|circumstances|situations}, revealing subtle {control|manage|handle} {over|more than} the apparent thermodynamic stability. We {discovered|found} that presence of a contaminant as low as 1.5% mol mol-1 acting as a template is {required|needed|necessary|essential|expected} to {enable|allow} all these {three|3} polymorph transformations. The relative stabilities {of the|from the|in the|on the|with the|of your} polymorphs are determined by the sizes {of the|from the|in the|on the|with the|of your} nanocrystals {produced|created|made|developed} {under|below|beneath} {different|various|distinct|diverse|unique|distinctive} {conditions|circumstances|situations} and by surface interactions with {small|little|tiny|modest|smaller|compact} amounts of added solvent. For {the first|the very first|the initial} time, we show {evidence|proof} that {each|every|each and every|every single} {of the|from the|in the|on the|with the|of your} {three|3} polymorphs is obtained {with a|having a|using a} {unique|distinctive|special|exclusive|exceptional|one of a kind} and reproducible crystalline size. This mechanochemical {approach|method|strategy} {gives|provides|offers} access to bulk quantities of metastable polymorphs {that are|which are|which can be|which might be|that happen to be} inaccessible {through|via|by means of|by way of} recrystallisation. Ethyl 2-formylisonicotinate Data Sheet 1360774-41-9 web PMID:23724934
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