Asymmetric electrocatalysis is poised {to provide|to supply} a {unique|distinctive|special|exclusive|exceptional|one of a kind} avenue for access to enantioenriched molecules {that are|which are|which can be|which might be|that happen to be} {difficult|tough|challenging|hard|tricky|complicated} to {obtain|acquire|get|receive} {through|via|by means of|by way of} {more|much more|a lot more|far more|additional|extra} {conventional|standard|traditional} approaches, {but the|however the} {development|improvement} of {efficient|effective} electrocatalysts capable of {highly|extremely|very|hugely} enantioselective transformations remains elusive. Towards this enviable {end|finish}, bifunctional electrocatalyst capable of {both|each} redox mediation and delivery of {high|higher} stereocontrol is {needed|required|necessary}. {Here|Right here} we disclose a novel TEMPO-BOX-ligated copper electrocatalyst that enables oxidative kinetic resolution of racemic 1,4-diols, affording diverse chiral 1,4-diols and γ-lactones with {good|great|excellent|very good|fantastic|superior} or {excellent|superb|outstanding|exceptional|great|fantastic} chemo-, regio, and enantioselectivity. We also show that this cooperative Cu/TEMPO-BOX catalytic {strategy|technique|method|approach|tactic} is applicable {to the|towards the|for the} electro-oxidative kinetic resolution of 1,2- and 1,3-amino alcohols. This {work|function|perform|operate} demonstrates the {potential|possible|prospective} of bifunctional electrocatalysis for asymmetric synthetic {methods|techniques|strategies|approaches|procedures|solutions} and we anticipate that {it will|it’ll|it’s going to|it is going to|it can} spur the {development|improvement} of new hybrid electrocatalysts to {realize|understand|recognize|comprehend} novel asymmetric electrocatalytic {methods|techniques|strategies|approaches|procedures|solutions}. 1639-66-3 Purity (S)-2-(3-Bromophenyl)pyrrolidine custom synthesis PMID:23075432
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