The reactions of transition metal complexes underpin {numerous|many|several|quite a few|a lot of|various} synthetic processes and catalytic transformations. {Typically|Usually|Normally|Generally|Commonly|Ordinarily}, this reactivity {involves|entails|requires|includes} the participation of empty and filled molecular orbitals centred {on the|around the} transition metal. Kinetically stabilised species, {such as|like|including|for example|for instance|which include} octahedral low-spin d6 transition metal complexes, {are not|aren’t|usually are not|will not be|are certainly not|are usually not} {expected|anticipated} to participate {directly|straight} in these reactions. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, novel approaches that exploit metal ligand-cooperativity {offer|provide|supply|offer you|present|give} an {opportunity|chance} to challenge these preconceptions. {Here|Right here} we show that inclusion of an aluminium-based ligand {into the|in to the} coordination sphere of neutral low-spin d6 iron {complex|complicated} {leads to|results in} unexpected reactivity. Complexes featuring an unsupported Fe–Al bond are capable {of the|from the|in the|on the|with the|of your} intermolecular C–H bond activation of pyridines. Mechanistic {analysis|evaluation} suggests that C–H activation proceeds {through|via|by means of|by way of} a reductive deprotonation in which the two metal centres (Fe and Al) act like a frustrated Lewis-pair. {Key|Important|Crucial|Essential} to this behaviour {is a|is really a|is actually a|can be a|is often a|is usually a} ground state destabilisation {of the|from the|in the|on the|with the|of your} d6 iron {complex|complicated}, brought about by the inclusion {of the|from the|in the|on the|with the|of your} electropositive aluminium-based ligand. These findings have {immediate|instant|quick} implications for the {design|style|design and style} of reagents and catalysts {based|primarily based} on 1st row transition metals. 6144-78-1 site 1252793-57-9 uses PMID:23829314
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