Neurodegenerative {diseases|illnesses|ailments} {such as|like|including|for example|for instance|which include} Alzheimer’s {diseases|illnesses|ailments} (AD) are {associated with|related to|connected with|linked to} progressive neuronal cell death {and a|along with a|as well as a|plus a|and also a|in addition to a} {common|typical|frequent|widespread|prevalent|popular} correlation is aberrant protein misfolding and aggregation {of the|from the|in the|on the|with the|of your} Aβ peptide. Transition metal ions (Cu, Fe and Zn) {have been|happen to be|have already been} shown to {promote|market} aggregation and oxidative {stress|tension|anxiety|pressure|strain} {through|via|by means of|by way of} formation of Aβ-metal complexes. {In this|Within this} context, integrating molecular scaffolds rationally is {used|utilized|employed|utilised|applied|made use of} {here|right here} to {generate|produce|create} multifunctional molecules as modulators for metal-induced abnormalities. This {work|function|perform|operate} encompasses two novel compounds (HL1 and HL2), the rationale behind the {design|style|design and style}, their synthesis, characterization and metal chelation {ability|capability|capacity|potential} [Cu(II) and Zn(II)]. The molecular frameworks {of the|from the|in the|on the|with the|of your} {designed|developed|created|made} compounds consist of stilbene as an Aβ interacting moiety; whereas N,N,O and N,N,N,O donor atoms are linked to {generate|produce|create} the metal chelation moiety. {Further|Additional}, we went on exploring their multifunctionality w.r.t. to (i) their metal chelating capacities (ii) their utility to modulate the aggregation pathways of {both|each} metal-free and metal-bound amyloid-β, (iii) scavenge {free|totally free|free of charge|cost-free|absolutely free|no cost} radicals, (iv) inhibit the activity of acetylcholinesterase and (v) cytotoxicity. {Moreover|Furthermore|In addition|Additionally}, the compounds {were|had been|have been} {able to|in a position to} sequester Cu2+ {from the|in the} Aβ-Cu {complex|complicated} and {thus|therefore|hence|as a result} disrupt the redox cycle. Molecular docking {studies|research} {were|had been|have been} also performed with Aβ and acetylcholinesterase enzyme. {Overall|General|All round}, the {studies|research} presented {here|right here} qualify these molecules as promising anti-Alzheimer’s candidates. Price of 2,4-Dichloro-6-ethoxyquinazoline 612501-45-8 Chemscene PMID:23381626
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