Chemical probes are {valuable|beneficial|useful|worthwhile|precious|important} tools to {explore|discover} the function of proteins. Incorporation of electrophiles into {small|little|tiny|modest|smaller|compact} molecules enables covalent capture of protein interactions and {provides|offers|gives|supplies|delivers} access to {powerful|potent|effective|strong|highly effective} technologies {including|such as|which includes|like} chemoproteomic profiling and reactive fragment screening. {Current|Present|Existing} approaches {have been|happen to be|have already been} largely {limited|restricted} to protein pockets containing cysteine, so establishing {strategies|methods|techniques|approaches|tactics} to target other amino acid residues {is essential|is crucial} to expanding the applicability across the proteome. {Here|Right here}, we profiled sulfur(VI) fluorides (SVI-F) as reactive functionalities {that can|that may|that will|that could|which will|which can} modify {multiple|numerous|several|a number of|many|various} residues {including|such as|which includes|like} Lys, Tyr, His and Ser, {thus|therefore|hence|as a result} {offering|providing|supplying} utility for targeting {almost|nearly|virtually|practically|just about|pretty much} any protein. These {studies|research} {provided|supplied|offered} an in-depth understanding of SVI-F functionalities, {including|such as|which includes|like} hydrolytic stability, protein reactivity and utility in chemoproteomics. Such insights {offer|provide|supply|offer you|present|give} a {valuable|beneficial|useful|worthwhile|precious|important} guide for the {prospective|potential} {design|style|design and style} of SVI-F-containing ligands for {various|numerous|different|a variety of|several|many} chemical biology workflows and illustrate the wide {range|variety} of proteins that SVI-Fs can capture, {thus|therefore|hence|as a result} highlighting the {opportunity|chance} for SVI-Fs to expand the liganded proteome. 1416263-25-6 Order 1247542-90-0 In stock PMID:24513027
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