NH-1,{2|two},3-Triazoles undergo a ring cleavage in reactions with fluorinated acid anhydrides (trifluoroacetic, difluoroaceticchlorodifluoroacetic and pentafluoropropionic anhydrides) by nitrogen acylation and acid-mediated triazole ring opening. Structurally diverse fluoroalkylated oxazoles {were|had been|have been} {prepared|ready} from {4|four},5-disubstituted-1,{2|two},3-triazoles. {Efficient|Effective} synthesis of 2-acylaminoketones was {achieved|accomplished} from 4-substituted-1,{2|two},3-triazoles. {Finally|Lastly|Ultimately}, {easy|simple|straightforward|effortless|uncomplicated|quick} access to fluoroalkylated imidazoles and 1,{2|two},4-tetrazines wasdeveloped by one-pot two step routes from fluorinated anhydrides and NH-triazoles. 1-Bromo-4-(trifluoromethyl)benzene Chemscene 8-Hydroxyoctanoic acid structure PMID:22943596
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