Aryl Fluorosulfate-Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase
The sirtuin enzymes are a {family|family members|loved ones|household} of lysine deacylases that regulate gene transcription and metabolism. Sirtuin {5|five} (SIRT5) hydrolyzes malonyl, succinyl, and glutaryl epsilon‐N‐carboxyacyllysine posttranslational modifications and has…