In mayonnaise, lipid and protein oxidation are closely {related|associated|connected} {and the|and also the|as well as the|along with the|plus the} interplay {between|in between|among|amongst|involving} them is {critical|crucial|vital|essential|important} for understanding the chemical shelf-life stability of mayonnaise. {This is|This really is|This can be|That is} in {particular|specific|certain|distinct|unique} the case for comprehending the {role|function|part} of low-density lipoprotein (LDL) particles as a {main|primary|principal|major|key|most important} emulsifier. {Here|Right here}, we monitored oxidation {and the|and also the|as well as the|along with the|plus the} concomitant aggregation of LDLs by {bright|vibrant} field light microscopy and cryogenic transmission electron microscopy. We {further|additional} probed the formation of protein radicals and protein oxidation by imaging the accumulation of a water-soluble fluorescent spintrap and protein autofluorescence. The {effect|impact} of variation of pH and addition of EDTA on accumulation of spintraps validated that protein radicals {were|had been|have been} induced by lipid radicals. We observed protein radical formation at {both|each} the oil/water droplet interface and {in the|within the|inside the} continuous phase. Our {data|information} suggests two {main|primary|principal|major|key|most important} pathways of oxidative protein radical formation in LDL particles: {at the|in the} droplet interface, induced by lipid {free|totally free|free of charge|cost-free|absolutely free|no cost} radicals formed in oil droplets, and {in the|within the|inside the} continuous phase induced by an independent LDL-specific mechanism. Formula of 3-Chloro-2-naphthoic acid 1172057-73-6 Data Sheet PMID:26760947
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