The {pressure|stress} of antimicrobial resistance has forced {many|numerous|several|a lot of|quite a few|lots of} {countries|nations} to {reduce|decrease|minimize|lessen|lower|cut down} {or even|or perhaps|and even} prohibit {the use of|the usage of} antibiotics in feed. {Therefore|Consequently|As a result|For that reason|Thus|Hence}, {it is|it’s|it really is|it truly is|it can be|it is actually} in urgent {need|require|want|need to have|will need|have to have} to {develop|create} {alternatives|options} to antibiotics to {control|manage|handle} infectious {diseases|illnesses|ailments} in feed and aquaculture. To address this long-lasting challenge, we {prepared|ready} peptide polymers that {display|show} potent and broad-spectrum activity against {common|typical|frequent|widespread|prevalent|popular} pathogenic bacteria in aquaculture, low hemolysis and low cytotoxicity, and {doesn’t|does not} induce bacteria to {develop|create} resistance or cross resistance to antibiotics. The optimal peptide polymer demonstrates {strong|powerful|robust|sturdy} in vivo therapeutic {potential|possible|prospective} in an adult zebrafish infection model. {Moreover|Furthermore|In addition|Additionally}, the optimal peptide polymer is biodegradable by enzyme into single amino acids and dipeptides to {totally|completely|entirely} {lose|shed|drop} antibacterial activity and, {therefore|consequently|as a result|for that reason|thus|hence}, {will not|won’t|is not going to} {cause|trigger|result in|lead to|bring about} antimicrobial selective {pressure|stress}. Our study suggests that peptide polymers are promising {alternatives|options} to antibiotics in aquaculture and open new avenues to address the {global|international|worldwide} challenge of antimicrobial resistance. Acetylferrocene Chemical name 4-Bromo-6-methyl-1H-indole uses PMID:23937941
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