{A new|A brand new} {method|technique|approach|strategy|system|process} for the one-step C‒H amination of xanthene and thioxanthene with sulfonamides is reported, {without|with out|without having|with no|devoid of|without the need of} the {need|require|want|need to have|will need|have to have} for any metal catalyst. A benzoquinone is employed as a hydride (or two-electron and one-proton) acceptor. {Moreover|Furthermore|In addition|Additionally}, a previously unknown and uncatalysed reaction {between|in between|among|amongst|involving} iminoiodanes and xanthene, thioxanthene and dihydroacridines (9,10-dihydro-9-hetero-anthracenes or dihydroheteroanthracenes) is disclosed. The reactions proceed {via|by way of|through|by means of} hydride transfer {from the|in the} heteroarene substrate {to the|towards the|for the} iminoiodane or benzoquinone, followed by conjugate addition {of the|from the|in the|on the|with the|of your} sulfonamide {to the|towards the|for the} oxidized heteroaromatic compounds. These findings {may have|might have} {important|essential|crucial|critical|significant|vital} mechanistic implications for metal-catalysed C‒H amination processes involving nitrene transfer from iminoiodanes to dihydroheteroanthracenes. {Due to|Because of|As a result of|On account of|Resulting from|As a consequence of} the weak C‒H bond, xanthene {is an|is definitely an} often-employed substrate in mechanistic {studies|research} of C‒H amination reactions, {which are|that are} {generally|usually|typically|normally|commonly|frequently} proposed to proceed {via|by way of|through|by means of} metal-catalysed nitrene insertion, {especially|particularly|specifically|specially|in particular} for reactions involving nitrene or imido complexes {that are|which are|which can be|which might be|that happen to be} {less|much less|significantly less} reactive (i.e. {less|much less|significantly less} strongly oxidizing). {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, these substrates clearly undergo non-catalysed (proton-coupled) redox coupling with amines, {thus|therefore|hence|as a result} {providing|supplying|offering|delivering|giving} {alternative|option} pathways {to the|towards the|for the} {widely|extensively|broadly} assumed metal-catalysed pathways. Thalidomide 5-fluoride Purity Formula of 55685-58-0 PMID:23912708
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