Superparamagnetic iron oxide nanoparticles (SPIONs) {generate|produce|create} heat upon exposure to an alternating magnetic field (AMF) which has been studied for hyperthermia {treatment|therapy|remedy} and triggered drug release. This study introduces a novel application of magnetic hyperthermia to induce amorphization of a poorly aqueous soluble drug, celecoxib, in situ in tablets for oral administration. In situ amorphization can overcome the drug {development|improvement} hurdle of poor aqueous solubility by molecularly dispersing the drug {in a|inside a|within a} polymeric network inside a tablet. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, {current|present|existing} shortcomings of this {approach|method|strategy} {include|consist of|contain|incorporate|include things like|involve} low drug loading {in the|within the|inside the} tablets, toxicity of enabling excipients, and drug degradation. {Here|Right here}, SPIONs {produced|created|made|developed} by flame spray pyrolysis are compacted with polyvinylpyrolidone and celecoxib, and exposed to an AMF. The degree of amorphization is strongly linked {to the|towards the|for the} maximum tablet temperature {achieved|accomplished} {during|throughout|in the course of|for the duration of|through} AMF exposure, which {depends on|depends upon|is determined by|is dependent upon|will depend on} SPION composition and {content|content material} {in the|within the|inside the} tablets. Manganese ferrites exhibit no toxicity in human intestinal Caco-2 cell lines and are {more|much more|a lot more|far more|additional|extra} {effective|efficient|successful|powerful|productive|helpful} than zinc ferrites in inducing {complete|total|full|comprehensive} amorphization of celecoxib. The resulting {rapid|fast|speedy} dissolution and {high|higher} solubility of in situ amorphized celecoxib in biorelevant intestinal fluid demonstrates the promising capability of SPIONs as enabling excipients to magnetically induce amorphization in situ in oral dosage {forms|types}. 6-Fluoro-4-iodopyridin-3-ol web 4-Acetylbenzaldehyde web PMID:22664133
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