Exploration {of the|from the|in the|on the|with the|of your} zwitterionic {property|home|house} of sulfur ylides has {long|lengthy|extended} been {known|recognized|identified} as a {flexible|versatile} {strategy|technique|method|approach|tactic} {in a|inside a|within a} wide {range of|selection of|array of} chemical transformations for {different|various|distinct|diverse|unique|distinctive} ring-sized {construction|building}. By contrast, their use in radical synthetic chemistry has been {significantly|considerably|substantially|drastically} {limited|restricted} {due to|because of|as a result of|on account of|resulting from|as a consequence of} dearth of {general|common|basic} activation {methods|techniques|strategies|approaches|procedures|solutions}. Herein, a {convenient|handy|hassle-free|practical|easy} {strategy|technique|method|approach|tactic} of visible light-driven proton-coupled electron transfer was reported to {enable|allow} sulfur ylides to decompose {into the|in to the} corresponding α-carbonyl carbon radicals. With this {method|technique|approach|strategy|system|process}, a {highly|extremely|very|hugely} selective 1,2-hydroxyacylmethylation {between|in between|among|amongst|involving} 1,3-dienes, sulfur ylides and water {under|below|beneath} photoredox catalysis is {thus|therefore|hence|as a result} {achieved|accomplished} (>40 examples). Preliminary mechanistic {studies|research} and theoretical calculations shed light {on the|around the} mechanism {and the|and also the|as well as the|along with the|plus the} origin of regioselectivity. Price of 1414958-33-0 5-Chloro-4-methylpyridin-3-amine Chemscene PMID:32180353
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