Lipid nanoparticles have {important|essential|crucial|critical|significant|vital} applications as biomedical delivery platforms and broader engineering biology applications in artificial cell technologies. These emerging technologies {often|frequently|usually|typically|generally|normally} {require|need|demand|call for} {changes|modifications|adjustments|alterations} {in the|within the|inside the} shape and topology of biological or biomimetic membranes. {Here|Right here} we show that topologically-active lyotropic liquid crystal nanoparticles (LCNPs) can trigger such transformations {in the|within the|inside the} membranes of giant unilamellar vesicles (GUVs). Monoolein (MO) LCNPs with an internal cubic nanostructure of space group Im3m incorporate into 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) GUVs {creating|making|producing|generating|developing|building} excess membrane {area|region|location} with stored curvature {stress|tension|anxiety|pressure|strain}. {Using|Utilizing|Making use of|Employing|Working with|Applying} real-time fluorescence confocal microscopy, we observe and characterise {various|numerous|different|a variety of|several|many} life-like dynamic events in these GUVs, {including|such as|which includes|like} {growth|development}, division, tubulation, membrane budding and fusion. Our {results|outcomes|final results|benefits} shed new light {on the|around the} interactions of LCNPs with bilayer lipid membranes, {providing|supplying|offering|delivering|giving} insights relevant to how these nanoparticles {might|may|may well|may possibly|could|could possibly} interact with cellular membranes {during|throughout|in the course of|for the duration of|through} drug delivery and highlighting their {potential|possible|prospective} as minimal triggers of topological transitions in artificial cells. 42166-64-3 manufacturer trans-Hexahydro-1H-furo[3,4-c]pyrrole site PMID:22664133
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