Dynamic nuclear polarization (DNP) {using|utilizing|making use of|employing|working with|applying} transient electron spin polarization generated by photoexcitation can {improve|enhance|boost|increase|strengthen} nuclear magnetic resonance (NMR) sensitivity far beyond the thermal equilibrium limit for {analysis|evaluation} in life science and drug discovery. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, DNP of liquid water at {room|space|area} temperature remains {an important|an essential|a crucial|a vital} challenge. In {previous|prior|earlier|preceding} {studies|research}, polarization has been transferred {directly|straight} {from the|in the} electron spins {in the|within the|inside the} {solid|strong} {to the|towards the|for the} nuclear spins {of the|from the|in the|on the|with the|of your} target, and this has been {limited|restricted} to near-surface {solid|strong} or highly-viscous targets. {Here|Right here}, we propose {a new|a brand new} {method|technique|approach|strategy|system|process} {called|known as|referred to as|named} hyperpolarization relay, in which the polarization of electron spins is transferred to proton spins {in the|within the|inside the} nanocrystals {and then|and after that|after which|then} to proton spins in bulk water by the nuclear Overhauser {effect|impact} (NOE). Molecular nanocrystals doped {with a|having a|using a} polarizing agent that generates a highly-polarized photoexcited triplet {were|had been|have been} synthesized by a reprecipitation {method|technique|approach|strategy|system|process} {while|whilst|although|even though|when|though} controlling the size {of the|from the|in the|on the|with the|of your} nanocrystals. {As the|Because the} size {of the|from the|in the|on the|with the|of your} nanocrystals decreases, the efficiency of polarization transfer from nanocrystals to water was {improved|enhanced} {due to|because of|as a result of|on account of|resulting from|as a consequence of} the {increase|improve|boost|enhance|raise} {in the|within the|inside the} surface {area|region|location}. Fmoc-Arg(Me,Pbf)-OH Chemscene 2-Amino-4-bromo-3-fluorobenzoic acid site PMID:23310954
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