An optimized catalytic protocol for enantio- and diastereoselective reduction of racemic α-CF3, α-SCF3 and α-OCF3 aryl ketones is described. The reaction {involves|entails|requires|includes} a dynamic kinetic resolution (DKR) {based|primarily based} on ruthenium catalyzed Noyori–Ikariya asymmetric transfer hydrogenation for simultaneous {construction|building} of two contiguous stereogenic centers. A {range|variety} of previously inaccessible fluorinated secondary alcohols was {prepared|ready} in {excellent|superb|outstanding|exceptional|great|fantastic} stereomeric purity ({up to|as much as} above 99.9% ee, {up to|as much as} above 99.9:0.1 dr) and in {high|higher} isolated yield ({up to|as much as} 99%). The origin of DKR (exceptional stereoselectivity and racemization mechanism) is rationalized by density functional theory calculations. Pharmaceutically relevant {further|additional} transformations {of the|from the|in the|on the|with the|of your} {products|goods|items|merchandise|solutions} are demonstrated {including|such as|which includes|like} incorporation into heat shock protein 90 inhibitor with in vitro anti-cancer activity. {Moreover|Furthermore|In addition|Additionally}, needle-shaped crystals of representative stereopure {products|goods|items|merchandise|solutions} are mechanically responsive: either elastically or plastically {flexible|versatile}, opening the door to novel class of functional {materials|supplies|components} {based|primarily based} on chiral molecular crystals. 7361-31-1 In stock Azido-PEG1 web PMID:23381626
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