A versatile polyene cyclization {strategy|technique|method|approach|tactic} was {developed|created} that exploits conjugated -ionyl derivatives. Photomediated disruption {of the|from the|in the|on the|with the|of your} extended -system {within|inside} these chromophores unveils a contra-thermodynamic polyene that engages {in a|inside a|within a} Heck-type cyclization to afford [4.{4|four}.1]-propellanes. The connectivity of overbred polycycles generated from this {process|procedure|method|approach|course of action} is controlled by the position {of the|from the|in the|on the|with the|of your} requisite C–Br bond. {Thus|Therefore|Hence|As a result}, {compared to|in comparison to|in comparison with|when compared with} {conventional|standard|traditional} biomimetic polyene cyclization, this {approach|method|strategy} {allows|enables|permits|makes it possible for} for {complete|total|full|comprehensive} {control|manage|handle} of regiochemistry and facilitates incorporation of {both|each} electron-rich and electron-deficient (hetero)aryl groups. This {strategy|technique|method|approach|tactic} was {successfully|effectively} applied {to the|towards the|for the} total synthesis of taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously {could not|couldn’t} be {prepared|ready} along {the same|exactly the same|the identical|precisely the same|the exact same} synthetic pathway. 3945-69-5 Chemscene 1807901-58-1 supplier PMID:24202965
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