Synthetic iron-sulfur cubanes are {essential|important|crucial|vital|necessary|critical} models for biological cofactors {in the|within the|inside the} {more|much more|a lot more|far more|additional|extra} {complex|complicated} enzymatic environments. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, a {complete|total|full|comprehensive} series of [Fe4S4]n complexes spanning all biorelevant oxidation states (n = 0-3+) has {never|by no means|in no way|never ever|under no circumstances} been {prepared|ready}. {Here|Right here}, we demonstrate that {the use of|the usage of} a bulky arylthiolate ligand {promoting|advertising} the encapsulation of alkali-metal cations {in the|within the|inside the} vicinity {of the|from the|in the|on the|with the|of your} cubane enables the synthesis of such a series. Characterization by EPR, 57Fe Mössbauer spectroscopy, UV-Vis electronic absorption and variable-temperature X-ray diffraction {analysis|evaluation} reveals {key|important|crucial|essential} trends for the Fe4S4 core’s geometry {as well|also|too|at the same time} as for the Mössbauer isomer shift, which {both|each} correlate systematically with oxidation state. {Furthermore|Moreover|In addition|Additionally}, we confirm the S=4 electronic ground state {of the|from the|in the|on the|with the|of your} most {reduced|decreased|lowered} member, [Fe4S4]0, in agreement with that proposed for the all-ferrous cubanes in Nature. Monomethyl auristatin E Price 1228595-79-6 uses PMID:23710097
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