The {development|improvement} of an asymmetric protocol for the reductive alkynylation of amides to access {important|essential|crucial|critical|significant|vital} alfa-chiral tertiary propargylic amines is reported {using|utilizing|making use of|employing|working with|applying} tandem Ir-catalyzed hydrosilylation/enantioselective Cu-catalyzed alkynylation. The reaction utilizes a Cu/PyBox catalyst {system|method|program|technique} {in the|within the|inside the} alkynylation step {to achieve|to attain} asymmetry and affords {excellent|superb|outstanding|exceptional|great|fantastic} yields with moderate to {good|great|excellent|very good|fantastic|superior} levels of enantiocontrol {while|whilst|although|even though|when|though} employing low Ir-catalyst loadings (0.{5|five} mol %). 1820570-42-0 Chemical name (4-Chlorophenyl)(2-nitrophenyl)sulfane Formula PMID:24507727
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