The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates {through|via|by means of|by way of} strain-release. Single pot {strategies|methods|techniques|approaches|tactics} {were|had been|have been} {further|additional} {developed|created} for the N-arylation of resulting azetidines, employing either SNAr reactions or Buchwald-Hartwig couplings. 2445347-90-8 structure (R)-1-(2-Methoxypyridin-4-yl)ethanamine manufacturer PMID:24381199
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