{Certain|Particular|Specific} cyanobacteria {of the|from the|in the|on the|with the|of your} secondary metabolite-rich order Nostocales can establish permanent symbioses {with a|having a|using a} {large|big|huge|massive|substantial|significant} {number|quantity} of cycads, by accumulating in their coralloid roots and shifting their metabolism to dinitrogen fixa-tion. {Here|Right here}, we report the discovery of two novel lipoglycopeptides, desmamides A (1) and B ({2|two}), {together|with each other|collectively} with their aglycone desmamide C ({3|three}), {from the|in the} nostocalean cyanobacterium Desmonostoc muscorum LEGE 12446 isolated from a cycad (Cycas revoluta) coralloid root. The chemical structures {of the|from the|in the|on the|with the|of your} compounds {were|had been|have been} elucidated {using|utilizing|making use of|employing|working with|applying} a {combination|mixture} of 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS). The desmamides are decapeptides, featuring O-glycosylation of tyrosine (in 1 and {2|two}) and an {unusual|uncommon} {3|three},5-dihydroxy-2-methyldecanoic acid residue. The biosynthesis {of the|from the|in the|on the|with the|of your} desmamides was studied by substrate feeding experiments and bioinformatics. We describe herein the dsm biosynthetic gene cluster (BGC) and propose it {to be|to become} {associated with|related to|connected with|linked to} desmamide production. The discovery of this class of {very|extremely|really|quite|incredibly|pretty} abundant (>1.5% d.w.) bacterial lipoglycopeptides paves the way for exploration of their {potential|possible|prospective} {role|function|part} in root endosymbiosis. Formula of Methyl 5-fluoro-2-methoxyisonicotinate Azido-PEG3-alcohol uses PMID:24732841
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