Target identification {is a|is really a|is actually a|can be a|is often a|is usually a} {critical|crucial|vital|essential|important} pillar {within|inside} the drug discovery {process|procedure|method|approach|course of action} that {involves|entails|requires|includes} deconvoluting the protein target of a pharmacologically active {small|little|tiny|modest|smaller|compact} molecule ligand. {While|Whilst|Although|Even though|When|Though} photoaffinity labeling {strategies|methods|techniques|approaches|tactics} have {become|turn out to be|grow to be|turn into|develop into|come to be} the benchmark for target deconvolution of {small|little|tiny|modest|smaller|compact} molecules owing to their reliance on external activation to induce covalent protein capture, the {process|procedure|method|approach|course of action} of target identification remains {one of the|among the|one of many|one of several|among the list of|on the list of} most technically {challenging|difficult} {aspects|elements} of early drug discovery. {Thus|Therefore|Hence|As a result}, {there is|there’s|there is certainly} a {strong|powerful|robust|sturdy} demand for new technologies that {allow|permit|enable|let} for controlled activation of chemical probes to covalently label their protein target. {Here|Right here}, we introduce an electroaffinity labeling (ECAL) platform which leverages {the use of|the usage of} a {small|little|tiny|modest|smaller|compact}, redox-active diazetidinone (DZE) functional group to {enable|allow} chemoproteomic-based target identification of pharmacophores {within|inside} {live|reside} cell environments. 1622843-37-1 Chemscene 4-Bromo-5-fluoro-2-methylpyridine custom synthesis PMID:24275718
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