Chiral gamma-branched aliphatic amines are present {in a|inside a|within a} {large|big|huge|massive|substantial|significant} {number|quantity} of pharmaceuticals and {natural|all-natural|organic} {products|goods|items|merchandise|solutions}. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, enanti-oselective {methods|techniques|strategies|approaches|procedures|solutions} to access these compounds are scarce, and {rely on|depend on} {the use of|the usage of} {designed|developed|created|made} chiral transition-metal complexes. Herein, {we have|we’ve|we’ve got} combined an organocatalytic {method|technique|approach|strategy|system|process} for the stereospecific isomerization of chiral allylic amines {with a|having a|using a} dia-stereoselective reduction {of the|from the|in the|on the|with the|of your} chiral imine/enamine intermediates, {leading|top|major} to gamma-trifluoromethylated aliphatic amines with two noncontiguous stereogenic centers, in {excellent|superb|outstanding|exceptional|great|fantastic} yields and with {high|higher} diastereo- and enantioselectivities. This {approach|method|strategy} has been {used|utilized|employed|utilised|applied|made use of} with {primary|main|major|principal|key} amine substrates. {Additionally|In addition|Furthermore|Moreover|Also|On top of that}, a gram-scale reaction demonstrates the applicability of this syn-thetic {procedure|process}. Buy2619509-30-5 Formula of 102045-96-5 PMID:23927631
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