{Complex|Complicated} coacervate microdroplets are membraneless compartments that selectively sequester biological molecules from their surroundings and {enhance|improve|boost} bioreactions. {Yet|However|But}, their use as protocell models and bioreactors has been {limited|restricted} owing to a lack of feasible {strategies|methods|techniques|approaches|tactics} {to prevent|to stop} their uncontrolled coalescence. Herein, we introduce an {approach|method|strategy} to mitigate coalescence of {complex|complicated} coacervate microdroplets {using|utilizing|making use of|employing|working with|applying} comb polyelectrolytes as stabilizers {while|whilst|although|even though|when|though} retaining the membraneless coacervate-water interfaces, {creating|making|producing|generating|developing|building} membraneless coacervate emulsions with months-long stabilities. Tunability of microdroplet size and stability is {achieved|accomplished} by regulation of comb polyelectrolyte concentration and molecular weight. Importantly, the comb polyelectrolyte-stabilized coacervate microdroplets spontaneously sequester and retain proteins {over|more than} extended periods. {Moreover|Furthermore|In addition|Additionally}, enhanced catalytic activity of proteins and {significant|substantial|considerable|important} ({up to|as much as} 10-fold) acceleration of bioreactions is {achieved|accomplished} in stabilized {complex|complicated} coacervate dispersions, even when stored for {up to|as much as} 48 hours. Our findings are {expected|anticipated} to expand the utility of {complex|complicated} coacervate microdroplets as artificial protocells, encapsulants, and bioreactors, {and also|as well as} facilitate their use in pharmaceutical, agricultural, {food|meals}, and cosmetics formulations. 889460-62-2 Chemscene 1210834-55-1 Order PMID:24103058
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