Glycosylative modification of peptides could {improve|enhance|boost|increase|strengthen} the pharmacological properties of peptide drugs and {deliver|provide} them {efficiently|effectively} {to the|towards the|for the} target {sites|websites|web sites|internet sites|web-sites|web pages}. Compared with O-/N-glycosides, C-glycosides exhibit {more|much more|a lot more|far more|additional|extra} metabolic stability. We {here|right here} disclose {the first|the very first|the initial} {example|instance} of visible-light promoted and Cu-catalyzed stereoselective C-glycosylations. The mild reaction {conditions|circumstances|situations} are compatible with {various|numerous|different|a variety of|several|many} carbohydrate substrates, {including|such as|which includes|like} a series of mono monosaccharides and disaccharide, and is amenable {to the|towards the|for the} synthesis of a wild {variety of|number of|selection of} C-glycoamino acids and C-glycopeptidomimetics with {good|great|excellent|very good|fantastic|superior} yields and {excellent|superb|outstanding|exceptional|great|fantastic} stereoselectivities. The dual-functional photocatalyst formed in situ {via|by way of|through|by means of} coordination of glycine derivatives and chiral phosphine Cu {complex|complicated} {could not|couldn’t} only catalyze the photoredox {process|procedure|method|approach|course of action} {but also|but additionally|but in addition} {control|manage|handle} the stereoselectivity of glycosylation reaction. BuyFmoc-Cys(Trt)-OH Formula of Methyl 4-hydroxythiophene-3-carboxylate PMID:24670464
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