We report {here|right here} the {successful|effective|productive|profitable|prosperous|thriving} implementation of radical hydrodifluoromethylation of unsaturated C-C bonds {via|by way of|through|by means of} an electroreductively triggered two-pronged {approach|method|strategy}. Preliminary mechanistic investigations {suggest|recommend} that the {key|important|crucial|essential} distinction {of the|from the|in the|on the|with the|of your} present {strategy|technique|method|approach|tactic} originates {from the|in the} reconciliation of {multiple|numerous|several|a number of|many|various} redox processes {under|below|beneath} {highly|extremely|very|hugely} {reducing|decreasing|lowering|minimizing} electrochemical {conditions|circumstances|situations}. The reaction {conditions|circumstances|situations} {can be|may be|could be|might be|is often|is usually} {chosen|selected} {based|primarily based} {on the|around the} electronic properties {of the|from the|in the|on the|with the|of your} alkenes of interest, highlighting the hydrodifluoromethylation of {both|each} unactivated and activated alkenes. Notably, the reaction delivers geminal (bis)difluoromethylated {products|goods|items|merchandise|solutions} from alkynes {in a|inside a|within a} single step by consecutive hydrodifluoromethylation, granting access to an underutilized 1,1,{3|three},3-tetrafluoropropan-2-yl functional group. The late-stage hydrodifluoromethylation of densely functionalized pharmaceutical agents {is also|can also be} presented. 62972-61-6 Data Sheet (1-Methylcyclopentyl)methanol Purity PMID:24025603
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