The application of microcrystal electron diffraction (microED) to a number of pharmaceutical compounds is reported. The examples and work detailed showcase the utility of microED as a routine method for the rapid collection, evaluation, and generation of structural data on a variety of pharmaceutically relevant compounds, requiring minimal sample preparation and generally devoid of the want for time-consuming vitrification and cryo transfer processes. The development of a scripted information processing workflow permitted for simultaneous collection and processing of electron diffraction information, additional expediting structural evaluation of fifteen compounds. (R)-2-Chloro-2-fluoroacetic acid Formula (S)-2-Methoxy-1-phenylethan-1-amine structure PMID:24065671