Reaction generality is critical in determining the general effect and usefulness of organic synthetic procedures. In contrast, contemporary generalization processes seem unable to meet the developing demand for robust methodology. We sought to develop an accelerated strategy towards attaining generality, inspired by phenotypic screening, that rapidly expands the scope and utility of synthetic methods. This method was validated by example of the metallaphotoredox decarboxylative arylation, resulting inside the discovery of a novel additive that overcomes lots of lingering limitations of this process and has significant mechanistic implications for nickel-catalyzed cross couplings in general. 2820536-71-6 site 12289-94-0 Price PMID:27108903